Science & Technology

The application of specifically configured magnetic fields as a means of positively affecting the partitioning, diffusion and transdermal passage of drug and other active molecules is the core expertise of WELLFULLY.

Having invented, developed and refined our patented technology to a high level of formulation and molecular specificity, Wellfully is able to leverage its intellectual property to achieve new levels of product performance far beyond that of normal formulation chemistry.

Diamagnetic Repulsion

The property where matter with paired electrons is repulsed by a magnetic field. WELLFULLY harnesses this force to control the rate, depth of penetration and delivery pathway of active ingredients during diffusion and partitioning.

Induced Charge Permeation

The property of a moving magnetic field to induce micro-fluidic flow conditions in the complex appendageal structures of the skin, in fabrics and on hard surfaces.

Energy Redirection

The property of surface charge accumulation involving the capture of motional energy of normal consumer behaviour during product use to alter surface flow characteristics and penetration in target barriers.

While WELLFULLY predominantly works with partner-owned and proprietary molecules and formulations, the results of which are confidential, WELLFULLY does make available some documentation, data and results to assist partners and collaborators to understand the benefits of magnetic micro-array drug delivery and its uses. The following links provide a selection of data that is available.

PUBLISHED JOURNAL ARTICLES

Journal of Pharmacy and Pharmacology
Benson H. A. E., Krishnan G., Liew Y., Wallace V.P., Edwards J., Enhanced skin permeation and hydration by magnetic field array: preliminary in-vitro and in-vivo assessment. J Pharm Pharmacol (in press)

Journal of Pharmaceutical Science 2009
Krishnan, G.; Edwards, J.; Chen, Y.; Benson, H. A. E., Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro. J Pharm Sci 2009. DOI

10.1002/jps.22024

Biopolymers 2008
Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Enhanced transdermal delivery of a dipeptide by dermaportation. Biopolymers 2008, 90, (5), 655-62.

Journal of Chromatography
Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E., Liquid chromatography assay for 5-aminolevulinic acid: application to in vitro assessment of skin penetration via Dermaportation. J Chromatogr B 2007, 852, (1-2), 49-55.

PEER REVIEWED PUBLICATIONS

JPP-urea – Enhanced skin permeation and hydration by magnetic field array: preliminary in vitro and in vivo assessment

Dipeptide Publication – full version – Enhanced transdermal delivery of a Dipeptide by dermaportation

JPS_NTX09 – Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in-vitro.

ALA-JChromo – Liquid chromatography assay for 5-aminolevulinic acid: application to in-vitro assessment of skin penetration via Dermaportation.

INTERNATIONAL PRESENTATIONS AND PUBLICATIONS

• Quirk, C.; Wallace, V. P.; Krishnan, G.; Benson, H. A. E., Magnetic enhanced transdermal drug delivery: in-vitro and in-vivo efficacy and mechanistic studies In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2010.
• Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Electromagnetophoresis: potential for enhanced skin penetration of peptides. In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
• Krishnan, G.; Wallace, V.; Edwards, J.; Benson, H. A. E., Electromagnetic field energy as a skin penetration enhancer: preliminary in-vitro and in-vivo assessment of skin permeation and hydration. In Controlled Release Society and Australasian Pharmaceutical Science Association Conference, Hobart, Tasmania, 2009.
• Benson, H. A. E.; Edwards, J.; Krishnan, G.; Namjoshi, S., Electromagnetophoresis: potential for enhanced skin penetration of drugs and cosmetics In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
• Benson, H. A. E.; Namjoshi, S.; Chen, Y.; Edwards, J., Enhanced transdermal delivery of a dipeptide by inductive energy. In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2008.
• Namjoshi, S.; Benson, H.; Chen, Y.; Edwards, J. Enhanced transdermal delivery of a dipeptide by Dermaportation, 4th International Peptide Symposium, Cairns, Qld, 2007; Cairns, Qld, 2007.
• Caccetta, R.; Eijkenboom, M.; Edwards, J.; Namjoshi, S.; Benson, H. A. E. Increased transdermal delivery of local anaesthetics by the novel penetration enhancement technology Dermaportation; in-vitro and in-vivo assessment, Pharmaceutical Science World Congress, Amsterdam, 2007; Amsterdam, 2007.
• Benson, H.; Caccetta, R.; Eijkenboom, M.; Edwards, J. Dermaportation treated skin is more permeable to Voltaren Emulgel, World Congress on Inflammation, Copenhagen, 2007; Copenhagen, 2007.
• Krishnan, G.; Caccetta, R.; Benson, H. A. E.; Edwards, J. Enhanced transdermal delivery of estradiol by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Adelaide, 2006; Adelaide, 2006.
• Benson, H. A. E.; Krishnan, G.; Caccetta, R.; Edwards, J. Dermaportation, a novel skin penetration enhancement technoloy: preliminary investigations with naltrexone, 10th Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2006; La Grande Motte, France, 2006.
• Benson, H. A. E.; Namjoshi, S.; Edwards, J., Dermal penetration enhancement by Dermaportation – Preliminary investigations of a novel technology. J Invest Dermatol 2005, 125, (6), A12.
• Benson, H. A. E.; Namjoshi, S.; Edwards, J. Dermal delivery enhancement by Dermaportation – a novel penetration enhancement technology, 39th Annual Conference of the Australian Society of Cosmetic Chemists, Brisbane, 2005; Brisbane, 2005.
• Benson, H. A. E.; Caccetta, R.; Namjoshi, S.; Edwards, J.; Eijkenboom, M. Rapid delivery of local anaesthetics by Dermaportation – a novel skin penetration enhencement technology, World Congress on Pain, Sydney, 2005; Sydney, 2005.
• Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E. Enhancement of skin penetration by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Melbourne, 2004; Melbourne, 2004.

BOOKLETS & INFORMATION SHEETS

The following is an introduction to OBJ’s technology platform and links to papers on test data.

• Technology and Introduction Booklet
• TS_In-Vivo Animal Vaccine Study
• TS_In-Vivo human Ametop clinical pilot
• eM-patch Cosmetic Booklet
• ETP & eM-patch Summary Results
• Mechanisms of Action
• TS_5-ALA_Low Concentration
• TS_ex-vivo _ETP & DP data summary
• TS_ex-vivo human_Hydrocortisone
• TS_ex-vivo human_Naltrexone
• TS_ex-vivo human_Voltaren
• TS_ex-vivo Caffeine